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CS-W001157 4
Total: USD 88.00

2,4-Difluoropyridine

  • CAS No. 34941-90-7

  • Cat. No. CS-W011239
  • Purity≥98%
  • MDL No.MFCD04114162

*For research and further manufacturing use only, not for direct human use.

2,4-Difluoropyridine|CS-W011239

Structure of 34941-90-7

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General Information

  • CAS No. 34941-90-7
  • Cat. No. CS-W011239
  • Purity ≥98%
  • MDL No. MFCD04114162
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃F₂N
  • Molecular Weight 115.08
  • Synonym(s) 2,4-DIFLUORO-PYRIDINE
  • SMILES FC1=NC=CC(=C1)F

Description

2,4-Difluoropyridine is a fluorinated heterocycle featuring two strategically positioned fluorine atoms that enhance electrophilicity at the C2 and C4 positions. This electron-deficient pyridine derivative serves as a key scaffold in medicinal chemistry, enabling efficient coupling reactions and facilitating metabolic stability in bioactive molecules.

Application

2,4-Difluoropyridine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at C3 via nucleophilic substitution due to the ortho/para directing effect of fluorine. Its bench-stable nature and compatibility with palladium-catalyzed cross-coupling reactions facilitate efficient access to diverse heterocyclic scaffolds. The molecule functions as a key intermediate in the synthesis of kinase inhibitors and other bioactive compounds, offering predictable regioselectivity and excellent functional group tolerance in standard synthetic workflows.

Synthesis

  • Route1
    • 3-Chloro-2,4-difluoropyridine|CS-0102228
      851179-01-6
    • ~77%
    • In-stock
      2,4-Difluoropyridine|CS-W011239
      34941-90-7

    References

    • Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred Chemistry - A European Journal, 2005 , vol. 11, # 6 p. 1903 - 1910
  • Route2

    References

    • Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred Chemistry - A European Journal, 2005 , vol. 11, # 6 p. 1903 - 1910
  • Route3
    • null|null
      837364-95-1
    • ~%
    • In-stock
      2,4-Difluoropyridine|CS-W011239
      34941-90-7

    References

    • Chemistry - A European Journal, , vol. 11, # 6 p. 1903 - 1910

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H225-H315-H319-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.3598
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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