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CS-W001157 4
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5-Formylpicolinic acid

  • CAS No. 53574-58-6

  • Cat. No. CS-0089586
  • Purity≥96%
  • MDL No.MFCD11100672

*For research and further manufacturing use only, not for direct human use.

5-Formylpicolinic acid|CS-0089586

Structure of 53574-58-6

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General Information

  • CAS No. 53574-58-6
  • Cat. No. CS-0089586
  • Purity ≥96%
  • MDL No. MFCD11100672
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅NO₃
  • Molecular Weight 151.12
  • Synonym(s) 5-Formylpyridine-2-carboxylic acid
  • SMILES O=C(C1=NC=C(C=O)C=C1)O

Description

5-Formylpicolinic acid delivers a reactive aldehyde group at the 5-position of a picolinic acid scaffold, enabling direct conjugation in bioconjugation and probe development. This electron-deficient heterocycle features enhanced solubility and stability under standard conditions, facilitating efficient coupling with nucleophiles such as hydrazides and amines.

Application

5-Formylpicolinic acid serves as a versatile building block in medicinal chemistry, enabling efficient access to heterocyclic scaffolds via condensation and cyclization reactions. Its ortho-aldehyde and carboxylic acid functionalities offer complementary reactivity for diversification, including amide formation, imine assembly, and transition-metal-catalyzed couplings. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis campaigns and API intermediate development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   67.26
  • LogP   0.5923
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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