Lot numbers can be found on the outside label of a product:
Methyl 6-formylnicotinate
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CAS No. 10165-86-3
- Cat. No. CS-D0517
- Purity≥95%
- MDL No.MFCD08275010
*For research and further manufacturing use only, not for direct human use.
Structure of 10165-86-3
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General Information
- CAS No. 10165-86-3
- Cat. No. CS-D0517
- Purity ≥95%
- MDL No. MFCD08275010
- Storage -20°C, sealed storage, away from moisture
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₇NO₃
- Molecular Weight 165.15
- Synonym(s) Methyl 6-formylpyridine-3-carboxylate
- SMILES O=C(C1=CC=C(C=O)N=C1)OC
Description
Methyl 6-formylnicotinate features a formyl group at the C6 position of the nicotinate ring, enabling direct functionalization in synthetic sequences. This electron-deficient heterocycle integrates readily into cross-coupling and conjugation workflows, offering high reactivity under mild conditions. The ester moiety enhances solubility in organic solvents while maintaining stability during standard bench handling.
Application
Methyl 6-formylnicotinate serves as a versatile building block in synthetic organic chemistry, enabling direct access to functionalized pyridine derivatives. The ortho-formyl group facilitates efficient aldol, Mannich, and reductive amination reactions, while the ester moiety supports selective transformations under mild conditions. Its bench-stable nature and compatibility with common protecting group strategies make it well-suited for multi-step synthesis of heterocyclic scaffolds and medicinal chemistry intermediates.
Synthesis
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Route1
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In-stock
5470-70-2 - ~68%
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In-stock
10165-86-3
References
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European Journal of Organic Chemistry, , # 26 p. 4412 - 4415
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Route2
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932382-16-6 - ~80%
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In-stock
10165-86-3
References
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Organic Letters, , vol. 16, # 2 p. 390 - 393
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Route3
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In-stock
56026-36-9 - ~%
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In-stock
10165-86-3
References
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Tetrahedron Letters, , vol. 47, # 39 p. 7025 - 7029
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 56.26
- LogP 0.6807
- H_Acceptors 4
- H_Donors 0
- Rotatable_Bonds 2
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