Lot numbers can be found on the outside label of a product:
tert-Butyl (3-amino-2,6-difluorophenyl)carbamate
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CAS No. 535170-20-8
- Cat. No. CS-0154434
- Purity≥97%
- MDL No.MFCD13182479
*For research and further manufacturing use only, not for direct human use.
Structure of 535170-20-8
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General Information
- CAS No. 535170-20-8
- Cat. No. CS-0154434
- Purity ≥97%
- MDL No. MFCD13182479
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₁H₁₄F₂N₂O₂
- Molecular Weight 244.24
- Synonym(s) Carbamic acid, (3-amino-2,6-difluorophenyl)-, 1,1-dimethylethyl ester (9CI)
- SMILES CC(C)(OC(NC1=C(F)C=CC(N)=C1F)=O)C
Description
tert-Butyl (3-amino-2,6-difluorophenyl)carbamate delivers a bench-stable, moisture-tolerant protecting group for ortho-difluorinated anilines. This carbamate anchors the amine selectively in complex synthesis, enabling efficient deprotection under mild acidic conditions while maintaining compatibility with diverse functional groups.
Application
tert-Butyl (3-amino-2,6-difluorophenyl)carbamate serves as a versatile building block in medicinal chemistry, enabling direct incorporation of ortho-fluorinated aniline motifs into complex scaffolds. The tert-butyl carbamate group provides excellent bench stability and facilitates straightforward deprotection under mild acidic conditions. Its compatibility with standard coupling reactions and tolerance to diverse functional groups supports efficient synthesis of fluorinated heterocycles and API intermediates.
Synthesis
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Route1
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535170-17-3 - ~86%
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In-stock
535170-20-8
References
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Youai Co., Ltd.; SHIM, Eun Kyong; KIM, Nam Doo; SHIM, Tae Bo; KIM, Seung Yong Patent: EP2647637 A2, 2013 ; Location in patent: Paragraph 0057 ;
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Route2
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In-stock
83141-10-0 - ~%
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In-stock
535170-20-8
References
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Kuramoto, Yasuhiro; Ohshita, Yoshihiro; Yoshida, Jiro; Yazaki, Akira; Shiro, Motoo; Koike, Tohru Journal of Medicinal Chemistry, 2003 , vol. 46, # 10 p. 1905 - 1917
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Route3
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In-stock
385-00-2 - ~%
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In-stock
535170-20-8
References
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Kuramoto, Yasuhiro; Ohshita, Yoshihiro; Yoshida, Jiro; Yazaki, Akira; Shiro, Motoo; Koike, Tohru Journal of Medicinal Chemistry, 2003 , vol. 46, # 10 p. 1905 - 1917
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 64.35
- LogP 2.894
- H_Acceptors 3
- H_Donors 2
- Rotatable_Bonds 1
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Key Words
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