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tert-Butyl (3-amino-4-fluorophenyl)carbamate

  • CAS No. 361548-95-0

  • Cat. No. CS-0040890
  • Purity≥98%
  • MDL No.MFCD04114550

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (3-amino-4-fluorophenyl)carbamate|CS-0040890

Structure of 361548-95-0

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General Information

  • CAS No. 361548-95-0
  • Cat. No. CS-0040890
  • Purity ≥98%
  • MDL No. MFCD04114550
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₅FN₂O₂
  • Molecular Weight 226.25
  • Synonym(s) tert-butyl N-(3-amino-4-fluorophenyl)carbamate
  • SMILES O=C(OC(C)(C)C)NC1=CC=C(F)C(N)=C1

Description

tert-Butyl (3-amino-4-fluorophenyl)carbamate delivers a protected amine and fluorinated aromatic moiety in a single, bench-stable entity. This carbamate derivative enables direct incorporation into peptide sequences or complex molecular architectures where regioselective functionalization and stability under standard conditions are critical.

Application

tert-Butyl (3-amino-4-fluorophenyl)carbamate serves as a key building block in medicinal chemistry, enabling the introduction of a 3-amino-4-fluorophenyl moiety with orthogonal protection. The tert-butyl carbamate group provides excellent bench stability and facilitates selective deprotection under mild acidic conditions. It reacts readily in standard coupling reactions, supports efficient functionalization at the amine site, and is compatible with diverse reaction environments, making it ideal for constructing bioactive heterocycles and API intermediates.

Synthesis

  • Route1

    References

    • Kuramoto, Yasuhiro; Ohshita, Yoshihiro; Yoshida, Jiro; Yazaki, Akira; Shiro, Motoo; Koike, Tohru Journal of Medicinal Chemistry, 2003 , vol. 46, # 10 p. 1905 - 1917
  • Route2

    References

    • Kuramoto, Yasuhiro; Ohshita, Yoshihiro; Yoshida, Jiro; Yazaki, Akira; Shiro, Motoo; Koike, Tohru Journal of Medicinal Chemistry, 2003 , vol. 46, # 10 p. 1905 - 1917
  • Route3

    References

    • Kuramoto, Yasuhiro; Ohshita, Yoshihiro; Yoshida, Jiro; Yazaki, Akira; Shiro, Motoo; Koike, Tohru Journal of Medicinal Chemistry, 2003 , vol. 46, # 10 p. 1905 - 1917

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   64.35
  • LogP   2.7549
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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