Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

2,6-Difluro-3-nitrobenzoic acid

  • CAS No. 83141-10-0

  • Cat. No. CS-W001228
  • Purity≥98%
  • MDL No.MFCD00119291

*For research and further manufacturing use only, not for direct human use.

2,6-Difluro-3-nitrobenzoic acid|CS-W001228

Structure of 83141-10-0

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 83141-10-0
  • Cat. No. CS-W001228
  • Purity ≥98%
  • MDL No. MFCD00119291
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₃F₂NO₄
  • Molecular Weight 203.10
  • Synonym(s) 2,6-Difluoro-3-nitrobenzoic acid
  • SMILES [O-][N+](=O)c1ccc(c(c1F)C(=O)O)F

Description

2,6-Difluoro-3-nitrobenzoic acid features a strategically positioned nitro group and two fluorine substituents that enhance electrophilicity and metabolic stability. This electron-deficient aromatic core integrates readily into synthetic routes requiring strong acceptor moieties. The carboxylic acid functionality enables direct coupling or derivatization under standard conditions.

Application

2,6-Difluoro-3-nitrobenzoic acid serves as a versatile building block in medicinal chemistry, enabling direct introduction of fluorinated aromatic scaffolds with orthogonal functional handles. The carboxylic acid facilitates amide coupling and esterification, while the nitro group offers a reliable handle for reduction to aniline derivatives. Fluorine substituents enhance metabolic stability and modulate electronic properties, making this compound well-suited for constructing bioactive heterocycles and drug-like molecules under standard synthetic conditions.

Synthesis

  • Route1

    References

    • Yoshida, Yoshiki; Barrett, David; Azami, Hidenori; Morinaga, Chizu; Matsumoto, Satoru; Matsumoto, Yoshimi; Takasugi, Hisashi Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 11 p. 2647 - 2666
  • Route2

    References

    • MITSUI CHEMICALS, INC. Patent: WO2006/137376 A1, 2006 ; Location in patent: Page/Page column 178 ;
  • Route3
    • null|null
      1309431-02-4
    • ~%
    • In-stock
      2,6-Difluro-3-nitrobenzoic acid|CS-W001228
      83141-10-0

    References

    • WO2011/63159 A1, ; Page/Page column 192 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   80.44
  • LogP   1.5712
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 2,6-Difluro-3-nitrobenzoic acid sigma2,6-Difluro-3-nitrobenzoic acid manufacturer2,6-Difluro-3-nitrobenzoic acid price2,6-Difluro-3-nitrobenzoic acid structure2,6-Difluro-3-nitrobenzoic acid SDSbuy 2,6-Difluro-3-nitrobenzoic acid2,6-Difluro-3-nitrobenzoic acid supplier2,6-Difluro-3-nitrobenzoic acid uses2,6-Difluro-3-nitrobenzoic acid molecular weightprice of 2,6-Difluro-3-nitrobenzoic acid2,6-Difluro-3-nitrobenzoic acid chemical name formula of 2,6-Difluro-3-nitrobenzoic acid
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label