2,6-Difluoro-4-hydroxybenzaldehyde

Name: 2,6-Difluoro-4-hydroxybenzaldehyde
Brand: ChemScene
Availability: InStock
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CAS No. 532967-21-8
Cat. No. CS-W009240
Purity≥98%
MDL No.MFCD07772042

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2,6-Difluoro-4-hydroxybenzaldehyde|CS-W009240

Structure of 532967-21-8

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General Information

CAS No. 532967-21-8
Cat. No. CS-W009240
Purity ≥98%
MDL No. MFCD07772042
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₄F₂O₂
Molecular Weight 158.10
Synonym(s) Benzaldehyde, 2,6-difluoro-4-hydroxy-
SMILES O=CC1=C(F)C=C(O)C=C1F

Description

2,6-Difluoro-4-hydroxybenzaldehyde features a strategically positioned aldehyde group flanked by two fluorine atoms and a phenolic hydroxyl, enabling direct functionalization in synthetic routes. The electron-withdrawing fluorines enhance electrophilicity at the carbonyl center while the hydroxyl group provides a handle for derivatization. This combination delivers high reactivity under mild conditions, facilitating efficient coupling reactions in pharmaceutical intermediates and specialty materials synthesis.

Application

2,6-Difluoro-4-hydroxybenzaldehyde serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated aromatic scaffolds. The ortho-fluorine substituents enhance metabolic stability and modulate electronic properties, while the aldehyde and phenolic hydroxyl groups provide orthogonal handles for downstream functionalization via condensation, coupling, or derivatization reactions. Bench-stable and compatible with standard synthetic workflows, it facilitates the construction of complex heterocycles and bioactive molecules.

Synthesis

Route1
- 68-12-2
- ~97%
- In-stock
  
  532967-21-8
References
- PFIZER PRODUCTS INC. Patent: WO2006/136924 A1, 2006 ; Location in patent: Page/Page column 136-137 ; WO 2006/136924 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 37.3
LogP 1.4829
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Aldehyde

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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2,6-Difluoro-4-hydroxybenzaldehyde

CAS No. 532967-21-8

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