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CS-W001157 4
Total: USD 88.00

2,6-Difluoro-4-methoxybenzaldehyde

  • CAS No. 256417-10-4

  • Cat. No. CS-W008448
  • Purity≥98%
  • MDL No.MFCD04114368

*For research and further manufacturing use only, not for direct human use.

2,6-Difluoro-4-methoxybenzaldehyde|CS-W008448

Structure of 256417-10-4

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General Information

  • CAS No. 256417-10-4
  • Cat. No. CS-W008448
  • Purity ≥98%
  • MDL No. MFCD04114368
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆F₂O₂
  • Molecular Weight 172.13
  • Synonym(s) 2,5-DIETHOXY BENZOYL CHLORIDE
  • SMILES O=CC1=C(F)C=C(OC)C=C1F

Description

2,6-Difluoro-4-methoxybenzaldehyde features a trifunctional aromatic core with electron-withdrawing fluorine atoms flanking a methoxy group and a reactive aldehyde. This configuration enables selective coupling in pharmaceutical synthesis, where steric and electronic tuning enhances reactivity under standard conditions.

Application

2,6-Difluoro-4-methoxybenzaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, offering enhanced metabolic stability through fluorine substitution and improved solubility via the methoxy group. Its aldehyde functionality enables efficient coupling reactions, including reductive amination and Grignard additions, while maintaining bench stability and compatibility with diverse functional groups under standard reaction conditions.

Synthesis

  • Route1
    • null|null
      4885-02-3
    • In-stock
      1,3-Difluoro-5-methoxybenzene|CS-W016404
      93343-10-3
    • ~18%
    • 2,4-Difluoro-6-methoxybenzaldehyde|CS-0465970
      608515-57-7
    • In-stock
      2,6-Difluoro-4-methoxybenzaldehyde|CS-W008448
      256417-10-4

    References

    • WO2007/30582 A2, ; Page/Page column 90 ; WO 2007/030582 A2
  • Route2
    • null|null
      68-12-2
    • ~%
    • In-stock
      2,6-Difluoro-4-methoxybenzaldehyde|CS-W008448
      256417-10-4

    References

    • WO2007/149448 A2, ; Page/Page column 68-69 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   1.7859
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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