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CS-W001157 4
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2-Fluoro-5-methylbenzaldehyde

  • CAS No. 93249-44-6

  • Cat. No. CS-W007737
  • Purity≥95%
  • MDL No.MFCD02093762

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-5-methylbenzaldehyde|CS-W007737

Structure of 93249-44-6

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General Information

  • CAS No. 93249-44-6
  • Cat. No. CS-W007737
  • Purity ≥95%
  • MDL No. MFCD02093762
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇FO
  • Molecular Weight 138.14
  • Synonym(s) 2-Fluor-5-methylbenzolcarbaldehyd
  • SMILES O=CC1=CC(C)=CC=C1F

Description

2-Fluoro-5-methylbenzaldehyde features a fluorine atom at the ortho position and a methyl group at the meta position relative to the aldehyde, creating a unique electronic profile. This electron-deficient aromatic scaffold enables selective coupling reactions in pharmaceutical synthesis, particularly in the construction of bioactive heterocycles. The aldehyde functionality provides a handle for nucleophilic addition and condensation chemistry under standard conditions.

Application

2-Fluoro-5-methylbenzaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient access to substituted benzimidazoles, heterocycles, and bioactive scaffolds. Its ortho-fluoro and meta-methyl groups provide enhanced metabolic stability and modulate electronic properties, while the aldehyde functionality facilitates imine formation, reductive amination, and coupling reactions. Bench-stable and readily purified by distillation or chromatography, it functions reliably in standard synthetic workflows.

Synthesis

  • Route1
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      352-32-9
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      4885-02-3
    • ~%
    • In-stock
      2-Fluoro-5-methylbenzaldehyde|CS-W007737
      93249-44-6
    • In-stock
      5-Fluoro-2-methylbenzaldehyde|CS-W011052
      22062-53-9

    References

    • US6350749 B1, ; Page column 134 - 135 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   1.94662
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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