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CS-W001157 4
Total: USD 88.00

2-Fluoro-3-methylbenzaldehyde

  • CAS No. 886762-64-7

  • Cat. No. CS-0186644
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-3-methylbenzaldehyde|CS-0186644

Structure of 886762-64-7

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General Information

  • CAS No. 886762-64-7
  • Cat. No. CS-0186644
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇FO
  • Molecular Weight 138.14
  • Synonym(s) Benzaldehyde,2-fluoro-3-methyl-
  • SMILES CC1=C(C(=CC=C1)C=O)F

Description

2-Fluoro-3-methylbenzaldehyde features a fluorinated aromatic ring with a methyl group at the meta position, delivering enhanced electron-withdrawing character and improved metabolic stability. This configuration supports efficient coupling in Suzuki-Miyaura and Ullmann reactions, enabling rapid access to functionalized biaryl scaffolds. The aldehyde moiety facilitates direct incorporation into heterocycles and amide linkages under mild conditions.

Application

2-Fluoro-3-methylbenzaldehyde serves as a versatile building block in medicinal chemistry, enabling the synthesis of substituted heterocycles and bioactive scaffolds. Its ortho-fluoro and meta-methyl substituents provide predictable electronic modulation and steric control, enhancing regioselectivity in electrophilic aromatic substitution and palladium-catalyzed coupling reactions. Bench-stable and compatible with standard purification methods, it facilitates efficient route development for API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   1.94662
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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