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3-Hydroxy-2-fluorobenzaldehyde

  • CAS No. 103438-86-4

  • Cat. No. CS-0029525
  • Purity≥98%
  • MDL No.MFCD11110191

*For research and further manufacturing use only, not for direct human use.

3-Hydroxy-2-fluorobenzaldehyde|CS-0029525

Structure of 103438-86-4

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General Information

  • CAS No. 103438-86-4
  • Cat. No. CS-0029525
  • Purity ≥98%
  • MDL No. MFCD11110191
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅FO₂
  • Molecular Weight 140.11
  • Synonym(s) 2-Fluoro-3-hydroxybenzaldehyde; 2-Fluoro-3-hydroxy-benzaldehyde
  • SMILES O=CC1=CC=CC(O)=C1F

Description

3-Hydroxy-2-fluorobenzaldehyde features a strategically positioned hydroxyl group adjacent to a fluorinated benzene ring, enabling enhanced reactivity in electrophilic substitution and facilitating chelation in transition metal complexes. This bench-stable scaffold integrates readily into pharmaceutical intermediates and functional materials, offering improved solubility and directional control in synthetic sequences.

Application

3-Hydroxy-2-fluorobenzaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of bioactive heterocycles. Its ortho-hydroxyl and fluorinated aromatic functionalities provide enhanced metabolic stability and targeted electronic effects, while the aldehyde group facilitates reliable condensation reactions. Bench-stable and compatible with standard purification methods, it functions effectively in multistep syntheses requiring functional group tolerance and predictable reactivity.

Synthesis

  • Route1

    References

    • Kirk, Kenneth L.; Olubajo, Olarangbe; Buchhold, Konstantin; Lewandowski, Gail A.; Gusovsky, Fabian; et al. Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 1982 - 1988
  • Route2

    References

    • Kirk, Kenneth L.; Olubajo, Olarangbe; Buchhold, Konstantin; Lewandowski, Gail A.; Gusovsky, Fabian; et al. Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 1982 - 1988
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    • In-stock
      3-Hydroxy-2-fluorobenzaldehyde|CS-0029525
      103438-86-4

    References

    • Kirk, Kenneth L.; Olubajo, Olarangbe; Buchhold, Konstantin; Lewandowski, Gail A.; Gusovsky, Fabian; et al. Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 1982 - 1988

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.3438
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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