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CS-W001157 4
Total: USD 88.00

3,5-Difluoro-4-(hydroxymethyl)phenol

  • CAS No. 438049-36-6

  • Cat. No. CS-0019187
  • Purity≥95%
  • MDL No.MFCD11040173

*For research and further manufacturing use only, not for direct human use.

3,5-Difluoro-4-(hydroxymethyl)phenol|CS-0019187

Structure of 438049-36-6

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General Information

  • CAS No. 438049-36-6
  • Cat. No. CS-0019187
  • Purity ≥95%
  • MDL No. MFCD11040173
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆F₂O₂
  • Molecular Weight None
  • Synonym(s) Benzenemethanol, 2,6-difluoro-4-hydroxy- (9CI)
  • SMILES OCC1=C(F)C=C(O)C=C1F

Description

3,5-Difluoro-4-(hydroxymethyl)phenol features a phenolic hydroxyl group flanked by two fluorine atoms at the meta positions, enhancing electron withdrawal and metabolic stability. The pendant hydroxymethyl functionality enables direct derivatization in synthesis workflows. This bench-stable compound serves as a key building block for bioactive scaffolds in medicinal chemistry.

Application

3,5-Difluoro-4-(hydroxymethyl)phenol serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the phenolic hydroxyl and ortho-fluorine sites. Its bench-stable nature and compatibility with standard coupling reactions facilitate efficient synthesis of fluorinated heterocycles and bioactive scaffolds. The hydroxymethyl group provides a handle for further derivatization, enhancing structural diversity in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07,GHS05
Signal Word : Danger
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P310-P312-P330-P332+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   1.1627
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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