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CS-W001157 4
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2-((Tert-butoxycarbonyl)amino)pentanoic acid

  • CAS No. 521286-38-4

  • Cat. No. CS-0453253
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-((Tert-butoxycarbonyl)amino)pentanoic acid|CS-0453253

Structure of 521286-38-4

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General Information

  • CAS No. 521286-38-4
  • Cat. No. CS-0453253
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₉NO₄
  • Molecular Weight 217.26
  • Synonym(s) rac-Boc Norvaline
  • SMILES CCCC(NC(OC(C)(C)C)=O)C(O)=O

Description

This protected amino acid derivative features a tert-butoxycarbonyl (Boc) group that ensures stability and ease of handling during peptide synthesis. The pentanoic acid side chain provides a hydrophobic anchor, enabling integration into diverse synthetic scaffolds. This compound streamlines access to functionalized peptides under standard conditions.

Application

2-((Tert-butoxycarbonyl)amino)pentanoic acid serves as a versatile building block in peptide synthesis and medicinal chemistry, enabling the introduction of a protected lysine-like side chain. The Boc-protected amine and carboxylic acid functionalities offer orthogonal reactivity for sequential coupling strategies. Its bench-stable solid form simplifies handling and purification, while the tert-butyl carbamate group permits efficient removal under mild acidic conditions, facilitating downstream functionalization in complex molecule assembly.

Synthesis

  • Route1

    References

    • Hoffmann-La Roche Inc. Patent: US5250517 A1, 1993 ; US 5250517 A

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   1.7644
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   4

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