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CS-W001157 4
Total: USD 88.00

Z-Nva-OH

  • CAS No. 21691-44-1

  • Cat. No. CS-0152583
  • Purity≥98%
  • MDL No.MFCD00063167

*For research and further manufacturing use only, not for direct human use.

Z-Nva-OH|CS-0152583

Structure of 21691-44-1

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General Information

  • CAS No. 21691-44-1
  • Cat. No. CS-0152583
  • Purity ≥98%
  • MDL No. MFCD00063167
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₇NO₄
  • Molecular Weight 251.28
  • Synonym(s) N-[(benzyloxy)carbonyl]-L-norvaline
  • SMILES CCC[C@H](NC(OCC1=CC=CC=C1)=O)C(O)=O

Description

Z-Nva-OH is a protected amino acid derivative featuring a norvaline backbone with an N-terminal carbobenzoxy (Cbz) group and a C-terminal hydroxyl functionality. This stable, bench-ready reagent facilitates efficient peptide coupling and side-chain modification workflows in synthetic biology and medicinal chemistry applications.

Application

Z-Nva-OH serves as a versatile building block in peptide synthesis, offering the N-protected variant of norvaline with enhanced stability and ease of purification. The benzoyl (Z) group provides reliable protection under standard deprotection conditions, while the aliphatic side chain enables efficient incorporation into diverse peptide scaffolds. Its bench-stable nature and compatibility with common coupling reagents facilitate robust workflow integration in both academic and industrial settings.

Synthesis

  • Route1
    • null|null
      134306-33-5
    • ~94%
    • In-stock
      Z-Nva-OH|CS-0152583
      21691-44-1

    References

    • Yu, Hui-Ming Journal of the Chinese Chemical Society, 1999 , vol. 46, # 5 p. 647 - 650
  • Route2
    • In-stock
      L-Norvaline|CS-D1371
      6600-40-4
    • null|null
      501-53-1
    • ~79%
    • In-stock
      Z-Nva-OH|CS-0152583
      21691-44-1

    References

    • Atherton; Hassall; Lambert Journal of Medicinal Chemistry, 1986 , vol. 29, # 1 p. 29 - 40
  • Route3
    • Methyl (s)-2-(((benzyloxy)carbonyl)amino)pentanoate|CS-0683894
      101650-08-2
    • ~%
    • In-stock
      Z-Nva-OH|CS-0152583
      21691-44-1

    References

    • Miyazawa, Toshifumi; Mio, Motoe; Watanabe, Yuko; Yamada, Takashi Canadian Journal of Chemistry, 2008 , vol. 86, # 3 p. 219 - 224

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   2.1661
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   6

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