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CS-W001157 4
Total: USD 88.00

(S)-3-hydroxydihydrofuran-2(3H)-one

  • CAS No. 52079-23-9

  • Cat. No. CS-0312594
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(S)-3-hydroxydihydrofuran-2(3H)-one|CS-0312594

Structure of 52079-23-9

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General Information

  • CAS No. 52079-23-9
  • Cat. No. CS-0312594
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₆O₃
  • Molecular Weight 102.09
  • Synonym(s) S-(-)-3-Hydroxy-gamma-butyrolactone
  • SMILES C1COC(=O)[C@H]1O

Description

(S)-3-hydroxydihydrofuran-2(3H)-one is a chiral, bench-stable heterocyclic building block featuring a hydroxyl group at the 3-position and a lactone carbonyl at the 2-position. This configuration enables selective functionalization in asymmetric synthesis, particularly in the construction of complex natural products and pharmaceutical intermediates. The molecule’s constrained ring system enhances regioselectivity during downstream transformations.

Synthesis

  • Route1

    References

    • AVECIA LIMITED Patent: WO2005/23737 A1, 2005 ; Location in patent: Page/Page column 10-12 ;
  • Route2
    • null|null
      4744-10-9
    • In-stock
      (S)-Malic acid|CS-W020132
      97-67-6
    • null|null
      104-15-4
    • ~%
    • In-stock
      (S)-3-hydroxydihydrofuran-2(3H)-one|CS-0312594
      52079-23-9

    References

    • American Cyanamid Company Patent: US4937235 A1, 1990 ;
  • Route3
    • null|null
      153011-58-6
    • ~%
    • In-stock
      (S)-3-hydroxydihydrofuran-2(3H)-one|CS-0312594
      52079-23-9

    References

    • Suzuki, Kenta; Takayama, Hiromitsu Organic Letters, 2006 , vol. 8, # 20 p. 4605 - 4608

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   -0.7058
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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