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CS-W001157 4
Total: USD 88.00

Mal-PEG6-acid

  • CAS No. 518044-42-3

  • Cat. No. CS-0108931
  • Purity≥95%
  • MDL No.MFCD22056307

*For research and further manufacturing use only, not for direct human use.

Mal-PEG6-acid|CS-0108931

Structure of 518044-42-3

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General Information

  • CAS No. 518044-42-3
  • Cat. No. CS-0108931
  • Purity ≥95%
  • MDL No. MFCD22056307
  • Storage -20°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₉H₃₁NO₁₀
  • Molecular Weight 433.45
  • Synonym(s) None
  • SMILES O=C(O)CCOCCOCCOCCOCCOCCOCCN1C(C=CC1=O)=O

Description

Mal-PEG6-acid features a maleimide group conjugated to a six-ethylene glycol unit, terminating in a carboxylic acid. This structure enables site-specific bioconjugation via thiol-Michael addition, while the PEG spacer enhances solubility and reduces aggregation. The terminal acid facilitates further coupling reactions under standard amine-functionalization conditions.

Application

Mal-PEG6-acid serves as a versatile bifunctional linker for conjugation and bioconjugation applications. The maleimide group enables site-specific, thioether bond formation with cysteine residues under physiological conditions, while the terminal carboxylic acid facilitates amide coupling or further derivatization. Its PEG6 spacer provides enhanced solubility and reduced steric hindrance, improving reactivity and stability in aqueous environments. Ideal for antibody-drug conjugate synthesis and peptide modification workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   130.06
  • LogP   -0.5143
  • H_Acceptors   9
  • H_Donors   1
  • Rotatable_Bonds   21

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