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CS-W001157 4
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N-[(1,1-Dimethylethoxy)carbonyl]-O-(1,1-dimethylethyl)-D-tyrosine

  • CAS No. 507276-74-6

  • Cat. No. CS-0208778
  • Purity≥97%
  • MDL No.MFCD01861337

*For research and further manufacturing use only, not for direct human use.

N-[(1,1-Dimethylethoxy)carbonyl]-O-(1,1-dimethylethyl)-D-tyrosine|CS-0208778

Structure of 507276-74-6

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General Information

  • CAS No. 507276-74-6
  • Cat. No. CS-0208778
  • Purity ≥97%
  • MDL No. MFCD01861337
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₈H₂₇NO₅
  • Molecular Weight 337.41
  • Synonym(s) N-α-(t-Butoxycarbonyl)-O-(t-butyl)-D-tyrosine
  • SMILES C([C@@H](NC(OC(C)(C)C)=O)C(O)=O)C1=CC=C(OC(C)(C)C)C=C1

Description

This protected D-tyrosine derivative features a tert-butoxycarbonyl group at nitrogen and a tert-butyl ester at oxygen, enabling stable incorporation into peptide chains. The orthogonal protection scheme facilitates selective deprotection during synthetic workflows, supporting efficient access to complex peptidic architectures under standard conditions.

Application

N-[(1,1-Dimethylethoxy)carbonyl]-O-(1,1-dimethylethyl)-D-tyrosine serves as a protected D-tyrosine building block for peptide synthesis, offering enhanced stability and orthogonal protection of both amine and phenolic hydroxyl groups. Its tert-butyl ester and carbamate functionalities enable facile deprotection under mild acidic conditions, facilitating efficient incorporation into complex peptide sequences with minimal epimerization.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H332
Precautionary Statements : P261-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

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Computational Chemistry Data

  • TPSA   84.86
  • LogP   3.3843
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   5

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