Fmoc-Tyr(tBu)-OH

Name: Fmoc-Tyr(tBu)-OH
Brand: ChemScene
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CAS No. 71989-38-3
Cat. No. CS-W008016
Purity≥98%
MDL No.MFCD00037129

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 71989-38-3

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General Information

CAS No. 71989-38-3
Cat. No. CS-W008016
Purity ≥98%
MDL No. MFCD00037129
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₈H₂₉NO₅
Molecular Weight 459.53
Synonym(s) None
SMILES O=C(O)[C@@H](NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)CC4=CC=C(OC(C)(C)C)C=C4

Description

Fmoc-Tyr(tBu)-OH features a protected tyrosine residue with a trifluoromethyl-substituted benzyl group, enabling stable incorporation into peptide chains. The fluorenylmethoxycarbonyl (Fmoc) handle ensures efficient, orthogonal deprotection during solid-phase synthesis. This derivative delivers high coupling yields and excellent solubility under standard conditions.

Application

Fmoc-Tyr(tBu)-OH serves as a cornerstone building block in solid-phase peptide synthesis, enabling efficient incorporation of tyrosine residues with orthogonal protection. The Fmoc group allows for mild base-mediated deprotection, while the *tert*-butyl side chain provides robust protection against undesired reactions. This derivative exhibits excellent stability, facilitates straightforward purification, and supports high coupling yields in diverse synthetic contexts.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 84.86
LogP 5.3983
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 7

Other Classifications

Bioactive Molecules Peptides

Life Science Amino Acids and their Derivatives Tyrosine and derivatives

Building Blocks Functional Group Fmoc

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Amino Acid Derivatives

Biochemistry Biochemicals and Reagents Amino Acids N-Protected Amino Acids

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Fmoc-Tyr(tBu)-OH

CAS No. 71989-38-3

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