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CS-W001157 4
Total: USD 88.00

(S)-DIFLUORPHOS

  • CAS No. 503538-70-3

  • Cat. No. CS-0087354
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(S)-DIFLUORPHOS|CS-0087354

Structure of 503538-70-3

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General Information

  • CAS No. 503538-70-3
  • Cat. No. CS-0087354
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₈H₂₄F₄O₄P₂
  • Molecular Weight 682.54
  • Synonym(s) Difluorphos
  • SMILES FC(O1)(F)OC2=C1C(C3=C(OC(F)(F)O4)C4=CC=C3P(C5=CC=CC=C5)C6=CC=CC=C6)=C(P(C7=CC=CC=C7)C8=CC=CC=C8)C=C2

Description

(S)-DIFLUORPHOS is a chiral phosphine ligand featuring two fluorine atoms that enhance electronic modulation and steric control in transition metal catalysis. This bench-stable, moisture-tolerant reagent integrates seamlessly into asymmetric synthesis workflows, enabling high enantioselectivity in cross-coupling and hydrogenation reactions.

Application

(S)-DIFLUORPHOS serves as a highly effective chiral ligand in transition-metal-catalyzed asymmetric transformations, particularly in palladium- and nickel-catalyzed cross-coupling reactions. Its fluorinated phosphine backbone enhances electronic modulation and steric control, enabling high enantioselectivity in C–C bond formation. The ligand exhibits excellent bench stability, ease of handling, and compatibility with diverse functional groups, making it a practical choice for iterative synthesis and process development in pharmaceutical and agrochemical R&D workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   36.92
  • LogP   7.513
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   7

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