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Structure of 503309-10-2
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This boronic acid features a fluorinated aryl moiety paired with a trifluoromethoxy group, delivering enhanced stability and electron-deficient character. It integrates efficiently into Suzuki-Miyaura cross-coupling reactions under standard conditions, enabling rapid access to complex fluorinated biaryls for medicinal chemistry and materials science applications.
(2-Fluoro-4-(trifluoromethoxy)phenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl scaffolds with enhanced metabolic stability. Its trifluoromethoxy group imparts favorable electronic and lipophilic properties, while the boronic acid functionality offers excellent bench stability and compatibility with diverse reaction conditions. The ortho-fluoro substituent provides potential for downstream functionalization via nucleophilic aromatic substitution or transition-metal-catalyzed coupling. This compound is particularly valuable in medicinal chemistry campaigns targeting CNS and oncology therapeutics.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: