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CS-W001157 4
Total: USD 88.00

2,6-Difluoro-4-methoxyphenylboronic acid

  • CAS No. 406482-20-0

  • Cat. No. CS-W010741
  • Purity≥95%
  • MDL No.MFCD05664299

*For research and further manufacturing use only, not for direct human use.

2,6-Difluoro-4-methoxyphenylboronic acid|CS-W010741

Structure of 406482-20-0

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General Information

  • CAS No. 406482-20-0
  • Cat. No. CS-W010741
  • Purity ≥95%
  • MDL No. MFCD05664299
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇BF₂O₃
  • Molecular Weight 187.94
  • Synonym(s) 2,6-Difluoro-4-methoxybenzeneboronic Acid (contains varying amounts of Anhydride)
  • SMILES FC1=C(C(=CC(=C1)OC)F)B(O)O

Description

2,6-Difluoro-4-methoxyphenylboronic acid features a boronic acid moiety flanked by two fluorine atoms and a methoxy group, enhancing its stability and reactivity in Suzuki-Miyaura coupling. The electron-withdrawing fluorines improve coupling efficiency, while the methoxy substituent supports solubility and minimizes protodeboronation. This compound enables reliable C–C bond formation under mild conditions.

Synthesis

  • Route1
    • 2-(3,5-Difluoro-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane|CS-0175545
      890839-37-9
    • ~43%
    • In-stock
      2,6-Difluoro-4-methoxyphenylboronic acid|CS-W010741
      406482-20-0

    References

    • WO2008/34859 A1, ; Page/Page column 40 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   49.69
  • LogP   -0.3468
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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