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CS-W001157 4
Total: USD 88.00

(2,5-Difluoro-4-methoxyphenyl)boronic acid

  • CAS No. 897958-93-9

  • Cat. No. CS-0176113
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(2,5-Difluoro-4-methoxyphenyl)boronic acid|CS-0176113

Structure of 897958-93-9

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General Information

  • CAS No. 897958-93-9
  • Cat. No. CS-0176113
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇BF₂O₃
  • Molecular Weight 187.94
  • Synonym(s) 2,5-Difluoro-4-methoxyphenylboronic acid
  • SMILES COC1=C(F)C=C(B(O)O)C(F)=C1

Description

This boronic acid features a difluorinated aromatic core paired with a methoxy substituent, delivering enhanced stability and solubility in polar solvents. The electron-deficient aryl ring enables efficient Suzuki-Miyaura coupling under mild conditions, while the boronic moiety remains bench-stable and moisture-tolerant, streamlining synthesis workflows in medicinal chemistry and materials science applications.

Application

(2,5-Difluoro-4-methoxyphenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl scaffolds with enhanced metabolic stability. The difluoro substitution pattern provides favorable electronic modulation and ortho-directed functionalization potential, while the methoxy group offers steric and electronic tuning. Bench-stable and compatible with diverse reaction conditions, it facilitates rapid access to substituted aryl motifs relevant to pharmaceutical and agrochemical synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

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Computational Chemistry Data

  • TPSA   49.69
  • LogP   -0.3468
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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