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CS-W001157 4
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5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-inden-1-one

  • CAS No. 214360-81-3

  • Cat. No. CS-0153846
  • Purity≥98%
  • MDL No.MFCD09264181

*For research and further manufacturing use only, not for direct human use.

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-inden-1-one|CS-0153846

Structure of 214360-81-3

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General Information

  • CAS No. 214360-81-3
  • Cat. No. CS-0153846
  • Purity ≥98%
  • MDL No. MFCD09264181
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₁₉BO₃
  • Molecular Weight 258.12
  • Synonym(s) 5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-indan-1-one
  • SMILES CC1(C)C(C)(C)OB(C2=CC=C3C(=C2)CCC3=O)O1

Description

This boronate-functionalized indenone integrates readily into Suzuki-Miyaura cross-coupling reactions under standard conditions. The tetramethylcyclopentadienylboronate moiety ensures high stability and moisture tolerance, enabling efficient C–C bond formation with aryl and heteroaryl halides.

Application

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-inden-1-one serves as a versatile boronate building block for Suzuki-Miyaura cross-coupling reactions. The tetramethylboronate moiety ensures excellent stability and ease of handling, while the indanone scaffold provides a rigid, functionalized platform for constructing complex heterocyclic and biaryl architectures. Its compatibility with diverse reaction conditions and straightforward purification make it ideal for medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   35.53
  • LogP   2.1147
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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