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CS-W001157 4
Total: USD 88.00

(3,5-Difluoro-4-methoxyphenyl)boronic acid

  • CAS No. 208641-98-9

  • Cat. No. CS-0080826
  • Purity≥97%
  • MDL No.MFCD08706257

*For research and further manufacturing use only, not for direct human use.

(3,5-Difluoro-4-methoxyphenyl)boronic acid|CS-0080826

Structure of 208641-98-9

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General Information

  • CAS No. 208641-98-9
  • Cat. No. CS-0080826
  • Purity ≥97%
  • MDL No. MFCD08706257
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇BF₂O₃
  • Molecular Weight None
  • Synonym(s) 3,5-DIFLUORO-4-METHOXY-PHENYLBORONIC ACID
  • SMILES OB(C1=CC(F)=C(OC)C(F)=C1)O

Description

This boronic acid features a difluorinated aromatic core paired with a methoxy substituent, enhancing electron deficiency and stability. The ortho-fluorine atoms facilitate selective cross-coupling reactions, while the methoxy group improves solubility and modulates reactivity under standard conditions.

Application

(3,5-Difluoro-4-methoxyphenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl scaffolds with enhanced metabolic stability. Its fluorinated aryl core provides favorable electronic properties and improved solubility, while the boronic acid functionality offers excellent bench stability and compatibility with diverse reaction conditions. The methoxy group enhances regioselectivity and facilitates downstream functionalization, making it a practical choice for medicinal chemistry and process-scale synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   49.69
  • LogP   -0.3468
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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