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CS-W001157 4
Total: USD 88.00

(2,6-Difluoro-4-hydroxyphenyl)boronic acid

  • CAS No. 957065-87-1

  • Cat. No. CS-0100645
  • Purity≥96%
  • MDL No.MFCD09878344

*For research and further manufacturing use only, not for direct human use.

(2,6-Difluoro-4-hydroxyphenyl)boronic acid|CS-0100645

Structure of 957065-87-1

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General Information

  • CAS No. 957065-87-1
  • Cat. No. CS-0100645
  • Purity ≥96%
  • MDL No. MFCD09878344
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BF₂O₃
  • Molecular Weight 173.91
  • Synonym(s) 4-Borono-3,5-difluorophenol
  • SMILES OB(C1=C(F)C=C(O)C=C1F)O

Description

This boronic acid features a difluorinated aromatic ring paired with a hydroxyl group, enabling enhanced solubility and stability in aqueous environments. The para-hydroxy functionality facilitates direct coupling in Suzuki-Miyaura reactions, while the ortho-fluorine substituents improve reactivity through electronic activation. Designed for bench-stable handling, it integrates efficiently into complex synthesis workflows requiring precise functional group compatibility.

Application

(2,6-Difluoro-4-hydroxyphenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of substituted biaryls and heteroaryl architectures. The ortho-difluoro substitution enhances electrophilic reactivity and improves metabolic stability in downstream pharmaceutical candidates. Its boronic acid functionality offers excellent bench stability, compatibility with diverse reaction conditions, and straightforward purification via standard aqueous workup.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   60.69
  • LogP   -0.6498
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   1

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