Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

2-Chloro-3-(trifluoromethyl)pyridine

  • CAS No. 65753-47-1

  • Cat. No. CS-W002203
  • Purity≥98%
  • MDL No.MFCD00042223
  • AREC Toxic Substance

*For research and further manufacturing use only, not for direct human use.

2-Chloro-3-(trifluoromethyl)pyridine|CS-W002203

Structure of 65753-47-1

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 65753-47-1
  • Cat. No. CS-W002203
  • Purity ≥98%
  • MDL No. MFCD00042223
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃ClF₃N
  • Molecular Weight 181.54
  • Synonym(s) 2-Chloro-3-trifuoromethylpyridine
  • SMILES Clc1ncccc1C(F)(F)F

Description

2-Chloro-3-(trifluoromethyl)pyridine features a trifluoromethyl group at the 3-position and a chlorine atom at the 2-position on the pyridine ring, creating a highly electron-deficient heterocyclic scaffold. This configuration enhances reactivity in cross-coupling processes and facilitates incorporation into bioactive molecules. The compound exhibits bench-stable handling characteristics and compatibility with standard synthetic protocols.

Application

2-Chloro-3-(trifluoromethyl)pyridine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions due to its electrophilic chlorine atom. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the pyridine core provides a rigid scaffold for targeted molecular design. Its bench-stable nature and compatibility with diverse functional groups facilitate efficient route optimization in multi-step syntheses.

Synthesis

  • Route1
    • null|null
      22253-72-1
    • ~49%
    • In-stock
      2-Chloro-5-(trifluoromethyl)pyridine|CS-W008770
      52334-81-3
    • In-stock
      2-Chloro-3-(trifluoromethyl)pyridine|CS-W002203
      65753-47-1

    References

    • US2012/259125 A1, ; Page/Page column 3 ;
  • Route2
    • null|null
      22253-72-1
    • ~92%
    • In-stock
      2-Chloro-3-(trifluoromethyl)pyridine|CS-W002203
      65753-47-1

    References

    • US2012/259125 A1, ; Page/Page column 3 ;
  • Route3

    References

    • European Journal of Organic Chemistry, , # 2 p. 327 - 330

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS06,GHS08
Signal Word : Danger
UN#: 2928
Class : 6.1 (8)
Packing Group : Ⅱ
Hazard Statements : H301+H311-H314-H372-H412
Precautionary Statements : P260-P264-P270-P273-P280-P301+P330+P331-P302+P352-P304+P340-P330-P361+P364-P363-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.7538
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 2-Chloro-3-(trifluoromethyl)pyridine sigma2-Chloro-3-(trifluoromethyl)pyridine manufacturer2-Chloro-3-(trifluoromethyl)pyridine price2-Chloro-3-(trifluoromethyl)pyridine structure2-Chloro-3-(trifluoromethyl)pyridine SDSbuy 2-Chloro-3-(trifluoromethyl)pyridine2-Chloro-3-(trifluoromethyl)pyridine supplier2-Chloro-3-(trifluoromethyl)pyridine uses2-Chloro-3-(trifluoromethyl)pyridine molecular weightprice of 2-Chloro-3-(trifluoromethyl)pyridine2-Chloro-3-(trifluoromethyl)pyridine chemical name formula of 2-Chloro-3-(trifluoromethyl)pyridine
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label