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CS-W001157 4
Total: USD 88.00

2-Chloro-3-iodopyridine

  • CAS No. 78607-36-0

  • Cat. No. CS-D0940
  • Purity≥98%
  • MDL No.MFCD00661298

*For research and further manufacturing use only, not for direct human use.

2-Chloro-3-iodopyridine|CS-D0940

Structure of 78607-36-0

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General Information

  • CAS No. 78607-36-0
  • Cat. No. CS-D0940
  • Purity ≥98%
  • MDL No. MFCD00661298
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClIN
  • Molecular Weight 239.44
  • Synonym(s) None
  • SMILES IC1=CC=CN=C1Cl

Description

2-Chloro-3-iodopyridine is a halogenated pyridine derivative featuring complementary reactive sites for cross-coupling. The chlorine and iodine substituents enable sequential functionalization, with the iodine group facilitating efficient palladium-catalyzed coupling reactions. This compound serves as a key building block in the synthesis of complex heterocyclic architectures.

Application

2-Chloro-3-iodopyridine serves as a versatile building block in cross-coupling chemistry, enabling palladium-catalyzed transformations to install diverse aryl and heteroaryl substituents. The ortho-chloro and meta-iodo groups provide orthogonal reactivity for sequential functionalization, facilitating the construction of complex pyridine-based scaffolds. Its bench-stable nature and compatibility with standard coupling conditions make it well-suited for iterative synthesis in medicinal chemistry and process development workflows.

Synthesis

  • Route1
    • null|null
      109-09-1
    • ~78%
    • In-stock
      2-Chloro-3-iodopyridine|CS-D0940
      78607-36-0

    References

    • Marzi, Elena; Bigi, Anna; Schlosser, Manfred European Journal of Organic Chemistry, 2001 , # 7 p. 1371 - 1376
  • Route2

    References

    • Kuethe, Jeffrey T.; Wong, Audrey; Davies, Ian W. Journal of Organic Chemistry, 2004 , vol. 69, # 22 p. 7752 - 7754
  • Route3
    • null|null
      109-09-1
    • ~65%
    • In-stock
      2-Chloro-4-iodopyridine|CS-D0941
      153034-86-7
    • In-stock
      2-Chloro-3-iodopyridine|CS-D0940
      78607-36-0

    References

    • Tetrahedron Letters, , vol. 45, # 42 p. 7873 - 7877

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.3396
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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