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CS-W001157 4
Total: USD 88.00

2-Chloropyridin-3-amine

  • CAS No. 6298-19-7

  • Cat. No. CS-W019980
  • Purity≥97%
  • MDL No.MFCD00006238

*For research and further manufacturing use only, not for direct human use.

2-Chloropyridin-3-amine|CS-W019980

Structure of 6298-19-7

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General Information

  • CAS No. 6298-19-7
  • Cat. No. CS-W019980
  • Purity ≥97%
  • MDL No. MFCD00006238
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅ClN₂
  • Molecular Weight 128.56
  • Synonym(s) None
  • SMILES NC1=CC=CN=C1Cl

Description

2-Chloropyridin-3-amine delivers a reactive chloro group at the 2-position and a primary amine at the 3-position on a pyridine scaffold, enabling direct coupling in cross-coupling reactions. This dual-functional motif supports efficient incorporation into pharmaceutical intermediates and functional materials.

Application

2-Chloropyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling direct nucleophilic substitution and palladium-catalyzed coupling reactions. Its ortho-chloro functionality facilitates efficient C–N bond formation, while the pyridin-3-amine moiety offers strong coordination and hydrogen-bonding capacity. The compound exhibits excellent bench stability and compatibility with diverse functional groups, simplifying purification and integration into multi-step syntheses of heterocyclic scaffolds and API intermediates.

Synthesis

  • Route1

    References

    • Malinowski, Marek Bulletin des Societes Chimiques Belges, 1988 , vol. 97, # 1 p. 51 - 54
  • Route2

    References

    • Reilly Industries, Inc. Patent: US5493028 A1, 1996 ;
  • Route3
    • null|null
      462-08-8
    • ~80%
    • In-stock
      2-Chloropyridin-3-amine|CS-W019980
      6298-19-7

    References

    • Dehmlow, Eckehard, V.; Schulz, Hans-Joachim Tetrahedron Letters, 1985 , vol. 26, # 40 p. 4903 - 4906

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.3172
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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