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CS-W001157 4
Total: USD 88.00

2-Chloro-3-nitropyridine

  • CAS No. 5470-18-8

  • Cat. No. CS-W007590
  • Purity≥98%
  • MDL No.MFCD00006232

*For research and further manufacturing use only, not for direct human use.

2-Chloro-3-nitropyridine|CS-W007590

Structure of 5470-18-8

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General Information

  • CAS No. 5470-18-8
  • Cat. No. CS-W007590
  • Purity ≥98%
  • MDL No. MFCD00006232
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClN₂O₂
  • Molecular Weight 158.54
  • Synonym(s) 2-chloro-3-nitro pyridine; 2-Chloro-3-nitropyridine
  • SMILES O=[N+](C1=CC=CN=C1Cl)[O-]

Description

It is employed as Na+ channel blocker, local anesthetic and cAMP production inhibitor. It acts as a surfactant molecule possessing both hydrophilic and lipophilic properties, adrenergic antagonist, EC 3.1.1.8 (cholinesterase) inhibitor and EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor.

Application

2-Chloro-3-nitropyridine serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. Its orthogonal reactivity profile—where the chloro group undergoes selective substitution while the nitro group remains intact—facilitates the construction of complex heterocyclic scaffolds. Bench-stable and compatible with standard purification methods, it functions reliably in diverse synthetic workflows for API development.

Synthesis

  • Route1

    References

    • Yakugaku Zasshi, , vol. 64, # 4 p. 201 Chem.Abstr., , p. 4717
  • Route2
    • 2-Ethoxy-3-nitropyridine|CS-0876183
      31594-44-2
    • ~86%
    • In-stock
      2-Chloro-3-nitropyridine|CS-W007590
      5470-18-8

    References

    • Lai, Long-Li; Lin, Pen-Yuan; Wang, Jy-Shih; Hwu, Jih Ru; Shiao, Min-Jen; Tsay, Shwu-Chen Journal of Chemical Research - Part S, 1996 , # 4 p. 194 - 195
  • Route3

    References

    • Lai, Long-Li; Lin, Pen-Yuan; Wang, Jy-Shih; Hwu, Jih Ru; Shiao, Min-Jen; Tsay, Shwu-Chen Journal of Chemical Research - Part S, 1996 , # 4 p. 194 - 195

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   56.03
  • LogP   1.6432
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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