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CS-W001157 4
Total: USD 88.00

2,5-Dichloro-3-nitropyridine

  • CAS No. 21427-62-3

  • Cat. No. CS-D1500
  • Purity≥98%
  • MDL No.MFCD06658963

*For research and further manufacturing use only, not for direct human use.

2,5-Dichloro-3-nitropyridine|CS-D1500

Structure of 21427-62-3

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General Information

  • CAS No. 21427-62-3
  • Cat. No. CS-D1500
  • Purity ≥98%
  • MDL No. MFCD06658963
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂Cl₂N₂O₂
  • Molecular Weight 192.99
  • Synonym(s) 2,5-Dichloro-3-nitropyridine
  • SMILES O=[N+](C1=CC(Cl)=CN=C1Cl)[O-]

Description

2,5-Dichloro-3-nitropyridine features a rigid pyridine core bearing two chloro substituents at the 2 and 5 positions and a nitro group at the 3 position. This electron-deficient heterocycle integrates readily into cross-coupling reactions and serves as a key intermediate in pharmaceutical synthesis. The compound exhibits bench-stable handling characteristics and tolerates standard reaction conditions.

Application

2,5-Dichloro-3-nitropyridine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling selective functionalization at the 3-position via nucleophilic substitution. The electron-deficient pyridine core facilitates regioselective coupling reactions, while the dichloro substituents provide orthogonal reactivity for sequential transformations. Its bench-stable nature and compatibility with standard cross-coupling protocols make it a practical scaffold for constructing complex heterocyclic systems.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H315-H318-H335
Precautionary Statements : P264-P270-P330-P405-P501

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Computational Chemistry Data

  • TPSA   56.03
  • LogP   2.2966
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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