Lot numbers can be found on the outside label of a product:
2,3-Dichloro-5-nitropyridine
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CAS No. 22353-40-8
- Cat. No. CS-W003123
- Purity≥98%
- MDL No.MFCD03840432
*For research and further manufacturing use only, not for direct human use.
Structure of 22353-40-8
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General Information
- CAS No. 22353-40-8
- Cat. No. CS-W003123
- Purity ≥98%
- MDL No. MFCD03840432
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₅H₂Cl₂N₂O₂
- Molecular Weight 192.99
- Synonym(s) 2,3-dichloro-5-nitro pyridine
- SMILES [O-][N+](=O)c1cnc(c(c1)Cl)Cl
Description
2,3-Dichloro-5-nitropyridine features a pyridine core functionalized with two chlorine atoms and a nitro group, enabling selective electrophilic substitution and serving as a key intermediate in the synthesis of pharmaceuticals and agrochemicals. The electron-deficient ring facilitates coupling reactions under mild conditions.
Application
2,3-Dichloro-5-nitropyridine serves as a versatile building block in heterocyclic synthesis, enabling efficient access to functionalized pyridine scaffolds. The dichloro substitution pattern facilitates selective nucleophilic aromatic substitution, while the nitro group provides a handle for reduction and subsequent coupling reactions. Its bench-stable nature and compatibility with standard reaction conditions make it ideal for medicinal chemistry campaigns and process development workflows.
Synthesis
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Route1
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In-stock
22353-38-4 - ~96%
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In-stock
22353-40-8
References
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Koch; Schnatterer Synthesis, 1990 , # 6 p. 499 - 501
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Route2
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In-stock
22353-38-4
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7732-18-5 - ~88%
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In-stock
22353-40-8
References
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Abbott Laboratories Patent: US6133253 A1, 2000 ;
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Route3
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In-stock
5418-51-9 - ~%
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In-stock
22353-40-8
References
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Synthesis, , # 6 p. 499 - 501
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS05,GHS06
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H301-H315-H318-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 56.03
- LogP 2.2966
- H_Acceptors 3
- H_Donors 0
- Rotatable_Bonds 1
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Key Words
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