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CS-W001157 4
Total: USD 88.00

1,4-Difluoro-2-nitrobenzene

  • CAS No. 364-74-9

  • Cat. No. CS-W010886
  • Purity≥97%
  • MDL No.MFCD00007054

*For research and further manufacturing use only, not for direct human use.

1,4-Difluoro-2-nitrobenzene|CS-W010886

Structure of 364-74-9

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General Information

  • CAS No. 364-74-9
  • Cat. No. CS-W010886
  • Purity ≥97%
  • MDL No. MFCD00007054
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃F₂NO₂
  • Molecular Weight 159.09
  • Synonym(s) Benzene, 1,4-difluoro-2-nitro-
  • SMILES O=[N+](C1=CC(F)=CC=C1F)[O-]

Description

2,5-Difluoronitrobenzene was used in the synthesis of :N-alkylated 2-arylaminobenzimidazolesquinoxalinonesN-(2-nitro-4-fluorophenyl)-l,2,3,4-tetrahydroisoquinoline

Application

1,4-Difluoro-2-nitrobenzene serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling nucleophilic aromatic substitution (SNAr) reactions under mild conditions. The ortho-fluorine atoms exhibit high reactivity toward amines, thiols, and alcohols, facilitating the construction of complex heterocyclic scaffolds and functionalized aryl linkages. Its bench-stable nature and compatibility with diverse functional groups make it ideal for multi-step synthesis workflows requiring selective transformation and purification.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06,GHS08
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H315-H319-H335-H373
Precautionary Statements : P260-P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   43.14
  • LogP   1.873
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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