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Structure of 446-11-7
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1-Fluoro-4-methyl-2-nitrobenzene features a fluorine atom at the ortho position relative to a nitro group, creating a highly electron-deficient aromatic system. This combination enables direct electrophilic substitution and facilitates transition metal-catalyzed coupling reactions. The methyl substituent enhances solubility and provides a handle for further functionalization. The molecule exhibits excellent bench stability and compatibility with standard synthetic protocols in medicinal chemistry and materials science applications.
1-Fluoro-4-methyl-2-nitrobenzene serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions due to its activated aryl fluoride functionality. The ortho-nitro group enhances electrophilicity, facilitating nucleophilic substitution under mild conditions. Its bench-stable nature and compatibility with diverse functional groups support efficient route development for complex heterocyclic scaffolds and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: