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CS-W001157 4
Total: USD 88.00

5-Chloro-2-fluoronitrobenzene

  • CAS No. 345-18-6

  • Cat. No. CS-W019164
  • Purity≥97%
  • MDL No.MFCD00069418

*For research and further manufacturing use only, not for direct human use.

5-Chloro-2-fluoronitrobenzene|CS-W019164

Structure of 345-18-6

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General Information

  • CAS No. 345-18-6
  • Cat. No. CS-W019164
  • Purity ≥97%
  • MDL No. MFCD00069418
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃ClFNO₂
  • Molecular Weight 175.55
  • Synonym(s) 4-Chloro-1-fluoro-2-nitrobenzene
  • SMILES C1=C(C(=CC=C1Cl)F)[N+](=O)[O-]

Application

5-Chloro-2-fluoronitrobenzene serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of substituted aromatic scaffolds. Its orthogonal reactivity profile—where the chloro and fluoro groups facilitate selective Suzuki-Miyaura and Buchwald-Hartwig couplings—supports modular assembly of complex heterocycles. The nitro group provides a handle for reduction to aniline intermediates, while the molecule exhibits good bench stability and ease of purification, making it well-suited for multi-step synthetic sequences in industrial R&D workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   43.14
  • LogP   2.3873
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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