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CS-W001157 4
Total: USD 88.00

2,3-Difluoronitrobenzene

  • CAS No. 6921-22-8

  • Cat. No. CS-W002615
  • Purity≥98%
  • MDL No.MFCD00456802
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2,3-Difluoronitrobenzene|CS-W002615

Structure of 6921-22-8

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Description

2,3-Difluoronitrobenzene features a highly reactive aromatic core with two fluorine atoms and a nitro group positioned ortho to each other. This electronic configuration enhances its utility in nucleophilic aromatic substitution reactions, enabling efficient functionalization under mild conditions. The molecule exhibits excellent bench stability and compatibility with diverse reaction media, making it a reliable building block for advanced synthetic sequences in medicinal chemistry and materials science.

Application

2,3-Difluoronitrobenzene serves as a versatile building block in nucleophilic aromatic substitution (SNAr) reactions, enabling efficient access to substituted anilines under mild conditions. Its dual fluorine substituents provide high reactivity at the ortho and meta positions relative to the nitro group, facilitating selective functionalization. The compound exhibits excellent bench stability and is compatible with a range of nucleophiles, including amines and thiols, making it well-suited for synthesizing pharmaceutical intermediates and agrochemical scaffolds.

General Information

  • CAS No. 6921-22-8
  • Cat. No. CS-W002615
  • Purity ≥98%
  • MDL No. MFCD00456802
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃F₂NO₂
  • Molecular Weight 159.09
  • Synonym(s) 1,2-Difluoro-3-nitrobenzene
  • SMILES O=[N+](C1=C(F)C(F)=CC=C1)[O-]

Computational Chemistry Data

  • TPSA   43.14
  • LogP   1.873
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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