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CS-W001157 4
Total: USD 88.00

2,3-Difluoroaniline

  • CAS No. 4519-40-8

  • Cat. No. CS-W007344
  • Purity≥98%
  • MDL No.MFCD00010298

*For research and further manufacturing use only, not for direct human use.

2,3-Difluoroaniline|CS-W007344

Structure of 4519-40-8

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General Information

  • CAS No. 4519-40-8
  • Cat. No. CS-W007344
  • Purity ≥98%
  • MDL No. MFCD00010298
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅F₂N
  • Molecular Weight 129.11
  • Synonym(s) 2,3-difluorobenzenamine
  • SMILES NC1=CC=CC(F)=C1F

Description

2,3-Difluoroaniline was used in the synthesis of ethyl 2-arylamino-4-trifluoromethylpyrimidine-5-carboxylate.

Application

2,3-Difluoroaniline serves as a valuable building block in medicinal chemistry and agrochemical synthesis, enabling the construction of fluorinated aromatic scaffolds. Its ortho-difluoro substitution pattern enhances metabolic stability and modulates electronic properties, while the primary amine group facilitates straightforward derivatization via coupling, acylation, or diazotization reactions. The compound exhibits good bench stability and is compatible with standard purification techniques, making it well-suited for use in multi-step synthetic sequences.

Synthesis

  • Route1
    • 1,2-Dichloro-3,4-difluorobenzene|CS-1189952
      36556-39-5
    • null|null
      1435-43-4
    • null|null
      136272-32-7
    • null|null
      136272-33-8
    • ~%
    • In-stock
      2,3-Difluoroaniline|CS-W007344
      4519-40-8

    References

    • US5041674 A1, ;
  • Route2
    • null|null
      87-61-6
    • ~%
    • In-stock
      2,3-Difluoroaniline|CS-W007344
      4519-40-8
    • In-stock
      NSC 127234|CS-W020001
      5509-65-9

    References

    • Journal of Fluorine Chemistry, , vol. 53, # 3 p. 379 - 386

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H227-H302+H312+H332-H315-H319-H335
Precautionary Statements : P210-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P403-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.547
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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