2-Chloro-5-hydroxypyrimidine

Name: 2-Chloro-5-hydroxypyrimidine
Brand: ChemScene
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CAS No. 4983-28-2
Cat. No. CS-W004687
Purity≥95%
MDL No.MFCD09743796

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 4983-28-2
Cat. No. CS-W004687
Purity ≥95%
MDL No. MFCD09743796
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₃ClN₂O
Molecular Weight 130.53
Synonym(s) 5-Pyrimidinol, 2-chloro-; 2-Chloro-5-hydroxypyrimidine
SMILES ClC1=NC=C(C=N1)O

Description

2-Chloro-5-hydroxypyrimidine features a reactive chlorine atom at the 2-position paired with a hydroxyl group at the 5-position, enabling selective functionalization. This bifunctional scaffold integrates readily into pharmaceutical intermediates and bioactive heterocycles under mild conditions. The compound exhibits stability under standard bench handling, facilitating its use in multi-step syntheses.

Application

2-Chloro-5-hydroxypyrimidine serves as a versatile building block in heterocyclic synthesis, enabling regioselective functionalization at the C5 position via nucleophilic substitution. Its hydroxyl group facilitates direct coupling or derivatization under mild conditions, while the C2 chloride supports efficient cross-coupling reactions with boronic acids and amines. The compound exhibits good bench stability and compatibility with common protecting group strategies, making it valuable for constructing pyrimidine-based scaffolds in medicinal chemistry and agrochemical research.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 46.01
LogP 0.8356
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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2-Chloro-5-hydroxypyrimidine

CAS No. 4983-28-2

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