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CS-W001157 4
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2-Chloro-5-(difluoromethoxy)pyrimidine

  • CAS No. 1192813-64-1

  • Cat. No. CS-0108795
  • Purity≥98%
  • MDL No.MFCD18415615

*For research and further manufacturing use only, not for direct human use.

2-Chloro-5-(difluoromethoxy)pyrimidine|CS-0108795

Structure of 1192813-64-1

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General Information

  • CAS No. 1192813-64-1
  • Cat. No. CS-0108795
  • Purity ≥98%
  • MDL No. MFCD18415615
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClF₂N₂O
  • Molecular Weight 180.54
  • Synonym(s) 2-chloro-5-difluoromethoxypyrimidine
  • SMILES FC(F)OC1=CN=C(Cl)N=C1

Description

2-Chloro-5-(difluoromethoxy)pyrimidine features a difluoromethoxy group that enhances metabolic stability and membrane permeability. This electron-deficient pyrimidine serves as a key building block in medicinal chemistry, enabling direct incorporation into kinase inhibitors and antiviral agents through robust coupling reactions under standard conditions.

Application

2-Chloro-5-(difluoromethoxy)pyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient Suzuki-Miyaura and Buchwald-Hartwig couplings due to its well-defined reactivity at the C2 position. The difluoromethoxy group enhances metabolic stability and modulates lipophilicity, while the pyrimidine core provides a robust scaffold for kinase inhibitor development. Bench-stable and readily purified by flash chromatography, it functions reliably in multi-step synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   35.01
  • LogP   1.7314
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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