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CS-W001157 4
Total: USD 88.00

2-(4-Bromopyridin-2-yl)propan-2-ol

  • CAS No. 477252-20-3

  • Cat. No. CS-W006275
  • Purity≥95%
  • MDL No.MFCD13190619

*For research and further manufacturing use only, not for direct human use.

2-(4-Bromopyridin-2-yl)propan-2-ol|CS-W006275

Structure of 477252-20-3

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General Information

  • CAS No. 477252-20-3
  • Cat. No. CS-W006275
  • Purity ≥95%
  • MDL No. MFCD13190619
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀BrNO
  • Molecular Weight 216.08
  • Synonym(s) None
  • SMILES CC(O)(C1=NC=CC(Br)=C1)C

Description

This bench-stable boronate ester integrates readily into Suzuki-Miyaura coupling reactions, featuring a sterically hindered tertiary alcohol and a bromopyridine handle for orthogonal functionalization.

Application

2-(4-Bromopyridin-2-yl)propan-2-ol serves as a valuable building block in medicinal chemistry, enabling efficient Suzuki-Miyaura and Buchwald-Hartwig coupling reactions. Its tertiary alcohol functionality provides enhanced bench stability and facilitates straightforward purification, while the bromopyridine moiety offers high reactivity in palladium-catalyzed transformations. This compound functions as a versatile scaffold for constructing biologically active heterocycles and API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   2.0715
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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