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CS-W001157 4
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1-Pyridin-3-ylethanol

  • CAS No. 4754-27-2

  • Cat. No. CS-0036932
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Pyridin-3-ylethanol|CS-0036932

Structure of 4754-27-2

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General Information

  • CAS No. 4754-27-2
  • Cat. No. CS-0036932
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉NO
  • Molecular Weight 123.15
  • Synonym(s) Methyl-3-pyridylcarbinol
  • SMILES CC(C1=CC=CN=C1)O

Description

1-Pyridin-3-ylethanol features a pyridin-3-yl group linked to a primary alcohol, delivering a versatile scaffold for medicinal chemistry and ligand design. The molecule combines electron-deficient aromatic character with a handleable hydroxyl functionality, enabling efficient derivatization under standard conditions. This bench-stable compound integrates readily into synthetic sequences requiring polar, heteroaromatic building blocks.

Application

1-Pyridin-3-ylethanol serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and drug-like scaffolds. Its pyridyl moiety offers favorable polarity and hydrogen-bonding capacity, while the primary alcohol facilitates straightforward derivatization via esterification, etherification, or oxidation to the corresponding aldehyde. The compound exhibits good bench stability and is compatible with standard synthetic protocols, making it well-suited for iterative synthesis campaigns and process development.

Synthesis

  • Route1
    • 1-(Pyridin-3-yl)ethanone Imatinib Impurity|CS-0229620
      350-03-8
    • ~99%
    • In-stock
      1-Pyridin-3-ylethanol|CS-0036932
      4754-27-2

    References

    • Organic Letters, , vol. 15, # 9 p. 2278 - 2281
  • Route2
    • null|null
      500-22-1
    • null|null
      75-16-1
    • ~76%
    • In-stock
      1-Pyridin-3-ylethanol|CS-0036932
      4754-27-2

    References

    • US2011/237584 A1, ; Page/Page column 131-132 ; US 20110237584 A1
  • Route3
    • In-stock
      3-Bromopyridine|CS-0008362
      626-55-1
    • null|null
      75-07-0
    • ~72%
    • In-stock
      1-Pyridin-3-ylethanol|CS-0036932
      4754-27-2

    References

    • Tetrahedron Letters, , vol. 40, # 23 p. 4339 - 4342

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   1.1349
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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