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CS-W001157 4
Total: USD 88.00

1-(5-Fluoro-2-hydroxyphenyl)ethanone

  • CAS No. 394-32-1

  • Cat. No. CS-W007851
  • Purity≥98%
  • MDL No.MFCD00011668

*For research and further manufacturing use only, not for direct human use.

1-(5-Fluoro-2-hydroxyphenyl)ethanone|CS-W007851

Structure of 394-32-1

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General Information

  • CAS No. 394-32-1
  • Cat. No. CS-W007851
  • Purity ≥98%
  • MDL No. MFCD00011668
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇FO₂
  • Molecular Weight 154.14
  • Synonym(s) Hydroxyphenyl)ethan-1-one
  • SMILES CC(C1=CC(F)=CC=C1O)=O

Description

1-(5-Fluoro-2-hydroxyphenyl)ethanone features a fluorinated aromatic ring bearing a hydroxyl group at the ortho position and a ketone functionality, enabling direct integration into bioactive scaffolds. The electron-withdrawing fluorine enhances metabolic stability, while the phenolic OH facilitates hydrogen bonding in target interactions. This compound serves as a key intermediate in pharmaceutical synthesis.

Application

1-(5-Fluoro-2-hydroxyphenyl)ethanone serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted phenolic ketones. Its ortho-hydroxy and fluoro substituents provide enhanced reactivity for electrophilic aromatic substitution and facilitate downstream functionalization via directed metalation or coupling reactions. The compound exhibits good bench stability and is compatible with standard purification protocols, making it well-suited for iterative synthesis of bioactive scaffolds.

Synthesis

  • Route1

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 1 p. 619 - 622
  • Route2

    References

    • Journal of Organic Chemistry, , vol. 19, p. 1617,1621 Bulletin de la Societe Chimique de France, , p. 629,632
  • Route3
    • null|null
      7446-70-0
    • In-stock
      4-Fluorophenyl acetate|CS-W018053
      405-51-6
    • ~%
    • In-stock
      1-(5-Fluoro-2-hydroxyphenyl)ethanone|CS-W007851
      394-32-1

    References

    • Journal of the American Chemical Society, , vol. 61, p. 161,164 US2334229 , ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.7339
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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