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Structure of 459-60-9
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1-Fluoro-4-methoxybenzene features a fluorine atom and a methoxy group positioned para to each other on a benzene ring, creating a highly electron-rich aromatic system with enhanced stability under standard conditions. This dual-functional substitution enables selective coupling reactions in synthetic chemistry, particularly in the construction of advanced pharmaceutical intermediates and functional materials where precise electronic tuning is required.
1-Fluoro-4-methoxybenzene serves as a versatile aryl building block in medicinal chemistry and materials science, enabling efficient Suzuki-Miyaura and Buchwald-Hartwig couplings due to its orthogonal reactivity profile. The fluoro and methoxy groups provide complementary functional handles for sequential transformations, while the molecule exhibits excellent bench stability and ease of purification.
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GHS Pictogram :
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GHS No : GHS02
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Signal Word : Warning
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UN#: 3271
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Class : 3
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Packing Group : Ⅲ
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Hazard Statements : H226
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Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P370+P378-P501
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Lot numbers can be found on the outside label of a product: