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CS-W001157 4
Total: USD 88.00

1-Fluoro-2-methoxybenzene

  • CAS No. 321-28-8

  • Cat. No. CS-W011162
  • Purity≥98%
  • MDL No.MFCD00000316

*For research and further manufacturing use only, not for direct human use.

1-Fluoro-2-methoxybenzene|CS-W011162

Structure of 321-28-8

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General Information

  • CAS No. 321-28-8
  • Cat. No. CS-W011162
  • Purity ≥98%
  • MDL No. MFCD00000316
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇FO
  • Molecular Weight 126.13
  • Synonym(s) Benzene, 1-fluoro-2-methoxy-
  • SMILES C1=CC=CC(=C1OC)F

Description

1-Fluoro-2-methoxybenzene features a strategically positioned fluorine atom and methoxy group on adjacent carbons, creating a unique electronic profile ideal for directing electrophilic substitution. This ortho-substituted aryl fluoride exhibits enhanced stability under standard reaction conditions while enabling selective functionalization in synthetic sequences.

Application

1-Fluoro-2-methoxybenzene serves as a versatile aryl building block in medicinal chemistry and agrochemical synthesis, enabling direct electrophilic substitution and transition-metal-catalyzed coupling reactions. Its ortho-fluoro-methoxy arrangement provides orthogonal reactivity for sequential functionalization, with the fluorine acting as a latent handle for nucleophilic substitution. Bench-stable and readily purified by distillation, it facilitates efficient construction of complex heterocyclic scaffolds and drug candidates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P370+P378-P501

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   1.8343
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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