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CS-W001157 4
Total: USD 88.00

2-Fluoro-1,4-dimethoxybenzene

  • CAS No. 82830-49-7

  • Cat. No. CS-W018011
  • Purity≥98%
  • MDL No.MFCD00042487

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-1,4-dimethoxybenzene|CS-W018011

Structure of 82830-49-7

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General Information

  • CAS No. 82830-49-7
  • Cat. No. CS-W018011
  • Purity ≥98%
  • MDL No. MFCD00042487
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉FO₂
  • Molecular Weight 156.15
  • Synonym(s) Hydrazine, (2,3,4,5,6-pentafluorophenyl)-
  • SMILES COC1=CC=C(OC)C(F)=C1

Description

2-Fluoro-1,4-dimethoxybenzene features a fluorine atom at the ortho position relative to one methoxy group, creating a distinct electronic profile. The para-oriented methoxy substituents enhance electron density while maintaining steric accessibility. This combination enables selective coupling reactions in pharmaceutical synthesis and offers improved stability under standard bench conditions.

Application

2-Fluoro-1,4-dimethoxybenzene serves as a versatile building block in medicinal chemistry and materials science, enabling efficient Suzuki-Miyaura and Buchwald-Hartwig coupling reactions due to its ortho-fluorine reactivity and stable methoxy substituents. The molecule exhibits excellent bench stability, facilitates straightforward purification, and functions as a key scaffold for heterocyclic and bioactive compound synthesis.

Synthesis

  • Route1
    • 2-Fluorocyclohexa-2,5-diene-1,4-dione|CS-0876371
      367-28-2
    • null|null
      77-78-1
    • ~44%
    • In-stock
      2-Fluoro-1,4-dimethoxybenzene|CS-W018011
      82830-49-7

    References

    • Glennon; Young; Benington; Morin Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1163 - 1168
  • Route2
    • 1,4-Dimethoxybenzene, 99%|CS-1269050
      150-78-7
    • ~45%
    • In-stock
      2-Fluoro-1,4-dimethoxybenzene|CS-W018011
      82830-49-7

    References

    • Davis, Franklin A.; Han, Wei; Murphy, Christopher K. Journal of Organic Chemistry, 1995 , vol. 60, # 15 p. 4730 - 4737

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H227-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   18.46
  • LogP   1.8429
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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