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CS-W001157 4
Total: USD 88.00

3-Fluoro-4-methoxyphenol

  • CAS No. 452-11-9

  • Cat. No. CS-W005810
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Fluoro-4-methoxyphenol|CS-W005810

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General Information

  • CAS No. 452-11-9
  • Cat. No. CS-W005810
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇FO₂
  • Molecular Weight 142.13
  • Synonym(s) 2-Fluoro-4-hydroxyanisole
  • SMILES OC1=CC=C(OC)C(F)=C1

Description

3-Fluoro-4-methoxyphenol features a fluorine atom at the meta position and a methoxy group at the para position relative to the phenolic hydroxyl, creating a uniquely polarized aromatic system. This configuration enhances solubility in organic solvents while maintaining stability under standard bench conditions. The compound serves as a key building block for bioactive molecule synthesis, particularly in pharmaceutical intermediates where modulated electron density and hydrogen-bonding capacity are critical.

Application

3-Fluoro-4-methoxyphenol serves as a valuable building block in medicinal chemistry, enabling the synthesis of fluorinated aromatic scaffolds with enhanced metabolic stability. Its ortho-fluoro and para-methoxy substituents provide complementary reactivity for palladium-catalyzed cross-couplings and electrophilic substitutions. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.46
  • LogP   1.5399
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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