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Structure of 93343-10-3
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1,3-Difluoro-5-methoxybenzene features a strategically positioned electron-rich methoxy group flanked by two fluorine substituents, delivering enhanced stability and tunable reactivity. This combination enables efficient coupling in cross-coupling processes and facilitates selective functionalization under standard conditions.
1,3-Difluoro-5-methoxybenzene serves as a valuable building block in medicinal chemistry, enabling the synthesis of fluorinated aromatic scaffolds via standard cross-coupling and electrophilic substitution reactions. Its ortho-fluorine substituents facilitate directed metallation, while the methoxy group offers moderate electron donation and compatibility with diverse functional groups. The compound exhibits excellent bench stability and ease of purification, making it well-suited for iterative synthetic workflows in API development and lead optimization.
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GHS No : GHS02
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Signal Word : Danger
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UN#: 1325
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Class : 4.1
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Packing Group : Ⅲ
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Hazard Statements : H226-H315-H319-H335
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Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501
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Lot numbers can be found on the outside label of a product: