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CS-W001157 4
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4-Methylpiperidin-2-one

  • CAS No. 4720-64-3

  • Cat. No. CS-0052341
  • Molecule weight113.16
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Methylpiperidin-2-one|CS-0052341

Structure of 4720-64-3

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General Information

  • CAS No. 4720-64-3
  • Cat. No. CS-0052341
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁NO
  • Molecular Weight 113.16
  • Synonym(s) 4-METHYL-2-PIPERIDINONE
  • SMILES CC1CCNC(=O)C1

Description

4-Methylpiperidin-2-one is a bench-stable, nitrogen-rich heterocycle featuring a ketone functionality at the 2-position and a methyl group at the 4-position. This structural motif enables direct incorporation into diverse synthetic scaffolds, particularly in medicinal chemistry and natural product synthesis. The molecule’s polarity and defined stereochemical environment support efficient derivatization under standard conditions.

Application

4-Methylpiperidin-2-one serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to bioactive scaffolds. Its amide functionality and sterically accessible nitrogen support diverse transformations, including reductive amination, nucleophilic substitution, and coupling reactions. The molecule exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for multi-step synthesis and process development workflows.

Synthesis

  • Route1
    • null|null
      916843-39-5
    • ~92%
    • In-stock
      4-Methylpiperidin-2-one|CS-0052341
      4720-64-3

    References

    • UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. Patent: WO2006/133303 A1, 2006 ; Location in patent: Page/Page column 84-85 ;
  • Route2
    • null|null
      172847-13-1
    • ~%
    • In-stock
      4-Methylpiperidin-2-one|CS-0052341
      4720-64-3
    • In-stock
      5-Methylpiperidin-2-one|CS-0009361
      3298-16-6

    References

    • SUNOVION PHARMACEUTICALS INC.; HARDY, Larry, Wendell; HEFFERNAN, Michele, L., R.; WU, Frank, Xinhe; SPEAR, Kerry, L.; SARASWAT, Lakshmi, D. Patent: WO2011/75699 A2, 2011 ; Location in patent: Page/Page column 149 ; WO 2011/075699 A1
  • Route3
    • null|null
      626-58-4
    • ~62%
    • In-stock
      4-Methylpiperidin-2-one|CS-0052341
      4720-64-3

    References

    • Wenkert, Ernest; Angell, E. Charles Synthetic Communications, 1988 , vol. 18, # 12 p. 1331 - 1338

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H225
Precautionary Statements : P210-P243-P273-P403

Quality Control

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Computational Chemistry Data

  • TPSA   29.1
  • LogP   0.5325
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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