tert-Butyl 3-(aminomethyl)-3-hydroxyazetidine-1-carboxylate

Name: tert-Butyl 3-(aminomethyl)-3-hydroxyazetidine-1-carboxylate
Brand: ChemScene
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CAS No. 1008526-71-3
Cat. No. CS-0039121
Purity≥97%
MDL No.MFCD17015986

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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tert-Butyl 3-(aminomethyl)-3-hydroxyazetidine-1-carboxylate|CS-0039121

Structure of 1008526-71-3

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General Information

CAS No. 1008526-71-3
Cat. No. CS-0039121
Purity ≥97%
MDL No. MFCD17015986
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₁₈N₂O₃
Molecular Weight 202.25
Synonym(s) 1-Boc-3-hydroxy-3-(aminomethyl)azetidine
SMILES CC(C)(OC(N1CC(C1)(O)CN)=O)C

Description

tert-Butyl 3-(aminomethyl)-3-hydroxyazetidine-1-carboxylate features a strained azetidine core bearing both hydroxyl and aminoalkyl functionalities, enabling direct incorporation into bioactive scaffolds. The tert-butyl ester group provides enhanced stability and facilitates convenient deprotection under mild acidic conditions. This compound serves as a key building block for medicinal chemistry campaigns targeting constrained peptide mimetics and kinase inhibitors.

Application

tert-Butyl 3-(aminomethyl)-3-hydroxyazetidine-1-carboxylate serves as a versatile building block for the synthesis of azetidine-containing scaffolds, enabling efficient access to biologically relevant heterocycles. The molecule combines a stable tert-butyl ester with a pendant primary amine and hydroxyl group, offering orthogonal functionalization potential. It facilitates straightforward derivatization via alkylation, acylation, or cyclization reactions, and demonstrates robust bench stability and ease of purification—ideal for medicinal chemistry campaigns and process development workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 75.79
LogP -0.0731
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Alcohol

Building Blocks Skeleton Aliphatic heterocycle compounds Azetidine compounds

Key Words

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tert-Butyl 3-(aminomethyl)-3-hydroxyazetidine-1-carboxylate

CAS No. 1008526-71-3

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