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CS-W001157 4
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(S)-2-(Aminomethyl)-1-N-Boc-piperidine

  • CAS No. 475105-35-2

  • Cat. No. CS-D1798
  • Purity≥95%
  • MDL No.MFCD06799358

*For research and further manufacturing use only, not for direct human use.

(S)-2-(Aminomethyl)-1-N-Boc-piperidine|CS-D1798

Structure of 475105-35-2

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General Information

  • CAS No. 475105-35-2
  • Cat. No. CS-D1798
  • Purity ≥95%
  • MDL No. MFCD06799358
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₂N₂O₂
  • Molecular Weight 214.30
  • Synonym(s) tert-Butyl (2S)-2-(aminomethyl)piperidine-1-carboxylate
  • SMILES O=C(OC(C)(C)C)N(CCCC1)[C@@H]1CN

Description

(S)-2-(Aminomethyl)-1-N-Boc-piperidine is a chiral building block featuring a protected amine and a pendant aminomethyl group, enabling direct incorporation into bioactive molecules. The Boc-protected nitrogen ensures stability during synthetic manipulations, while the (S)-configuration provides defined stereochemical control for asymmetric synthesis. This scaffold integrates readily into peptidomimetics and pharmaceutical intermediates under standard conditions.

Application

(S)-2-(Aminomethyl)-1-N-Boc-piperidine serves as a versatile chiral building block for the synthesis of bioactive molecules, enabling efficient access to piperidine-containing scaffolds. The Boc-protected amine offers excellent stability and orthogonal deprotection compatibility, while the pendant primary amine facilitates diverse functionalizations. This compound functions effectively in standard coupling reactions, reductive amination protocols, and heterocycle construction, supporting scalable, bench-friendly workflows in medicinal chemistry and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314-H318
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   55.56
  • LogP   1.7347
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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