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CS-W001157 4
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(S)-tert-Butyl (piperidin-2-ylmethyl)carbamate

  • CAS No. 139004-93-6

  • Cat. No. CS-W006924
  • Molecule weight214.30
  • Purity≥95%
  • MDL No.MFCD11975335

*For research and further manufacturing use only, not for direct human use.

(S)-tert-Butyl (piperidin-2-ylmethyl)carbamate|CS-W006924

Structure of 139004-93-6

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General Information

  • CAS No. 139004-93-6
  • Cat. No. CS-W006924
  • Purity ≥95%
  • MDL No. MFCD11975335
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₂N₂O₂
  • Molecular Weight 214.30
  • Synonym(s) tert-butyl N-[(2S)-piperidin-2-ylmethyl]carbamate
  • SMILES O=C(OC(C)(C)C)NC[C@H]1NCCCC1

Description

(S)-tert-Butyl (piperidin-2-ylmethyl)carbamate is a chiral building block featuring a stereogenic center at the piperidine ring junction. This protected amine integrates readily into complex molecular architectures, offering high stability under standard conditions and compatibility with diverse synthetic transformations. The tert-butyl carbamate group enables selective deprotection in late-stage functionalization.

Application

(S)-tert-Butyl (piperidin-2-ylmethyl)carbamate serves as a chiral building block for the synthesis of bioactive amines and nitrogen-containing heterocycles. Its pendant piperidine moiety enables facile functionalization, while the Boc group provides orthogonal protection compatible with standard deprotection protocols. The molecule exhibits good bench stability and facilitates efficient access to complex scaffolds in medicinal chemistry workflows.

Synthesis

  • Route1
    • null|null
      248914-23-0
    • ~88%
    • In-stock
      (S)-tert-Butyl (piperidin-2-ylmethyl)carbamate|CS-W006924
      139004-93-6

    References

    • GLAXO GROUP LIMITED Patent: WO2009/34133 A1, 2009 ; Location in patent: Page/Page column 14-15 ; WO 2009/034133 A1
  • Route2

    References

    • Perumattam, John; Shearer, Barry G.; Confer, William L.; Mathew, Rose M. Tetrahedron Letters, 1991 , vol. 32, # 49 p. 7183 - 7186
  • Route3

    References

    • Perumattam, John; Shearer, Barry G.; Confer, William L.; Mathew, Rose M. Tetrahedron Letters, 1991 , vol. 32, # 49 p. 7183 - 7186

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.36
  • LogP   1.6532
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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